Presenteartigo does not aim at absolutely to the quarrel of the fisiopatologia of quaisquerdoenas mentioned here, what it competes to the Reumatologia, however, one brief communication to the lay reader concerning the functioning of the Imunolgicohumano System fits-nosfazer, as well as of the disfunes that unchain the doenasauto-immune calls. The quarrel object, in this work, will be possible relaoentre upheavals of ' ' romance familiar' ' and the related disfunes imunolgicasque deflagram this pathological picture, that is currently important cause temporary or permanent deincapacidade in the whole world. Since the decade of 70, when the psychologist Robert Ader and the imunologista NicholasConhem had carried through experiments with imunossupressores in rats, it became-sepraticamente undisputed the direct relation between psychic stimulatons and the SistemImunolgico. In this experience, the scientists sacarinajuntamente gave verbal way with a imunossupressora drug, what, evidently, she depressed aimunidade of animals, taking them to develop it infections. Treated taisinfeces, she was given only saccharin and, conditional to the palate, its SistemasImunolgicos again was depressed and them they came back to contract queos infections led to the death. The humanity was ahead of an important comprovaocientfica of the psychic influence in the imunolgica reply. The linking between emotion and imunidadese of the one in the measure where the Lmbico System, responsible for the Nervous interaction between osSistemas, Endcrino and Imunolgico, has as one of its components ohipotlamo, that, in a citizen psychically balanced, it exerts certain regulaoda amount and of the quality of the stimulatons that must arrive at the SNC, beyond sero responsible for the notion of reward and punishment, what it promotes the atividadeafetiva in the individual. Without nosaprofundarmos in the physiology it estresse of it, already it is possible to observe the estreitarelao between emotion and Imunolgico System, what it allows in them to approach subject considered under atica of the Psiconeuroimunologia. Auto-immune illnesses are those where oSistema Imunolgico starts to recognize weaveeed of the proper body as agenteshostis, fighting them and promoting its destruction.